Gelatin for 3D bioprinting and tissue engineering
Gelatin is a popular choice of biomaterial for bioprinting research. Rousselot’s X-Pure® gelatin stands out with unparalleled purity and customizable properties, enabling researchers to translate their research into clinical applications.
Medical grade gelatins
Discover our X-Pure solutions
Insights
A medical revolution: 3D bioprinting
Emerging technologies like 3D bioprinting bring new options for developing treatments to repair or regenerate injured and diseased tissues and organs.
X-Pure for 3D bioprinting and tissue engineering
The X-Pure range, which includes the photocurable gelatins X-Pure GelMA and GelDAT, offers tunable physicochemical properties. Rousselot provides a variety of gelatins that can be used to produce RGD-rich matrices with varying stiffness, ranging from soft intestinal tissues to hard bony structures.
Unique functionalities and properties
Why choose X-Pure?
Compliance
All X-Pure gelatins meet the requirements of major pharmacopoeias and support regulatory compliance with the EU Medical Device Regulation (MDR) 2017/745 and ISO 22442. These materials offer full traceability, readily available documentation, and validated viral inactivation, streamlining the path to clinical use.
Consistency
With X-Pure, there's no need to adjust your printer settings when receiving a new batch, providing seamless consistency and ease of use. X-Pure helps eliminate data variability, ensuring reproducible and consistent results for efficient clinical translation while supporting the biocompatibility and biodegradability of your final application. X-Pure gelatins, including GelMA, are thermostable at 37°C, purified, and consistently produced under GMP conditions.1
High purity
Pyrogens that can be found in food-grade gelatin can cause inflammation when directly introduced in the body. Impurities may also skew cellular responses.2 X-Pure, with ultra-low endotoxin levels (≤10 EU/g), maintains natural cell activity, making it ideal for even the most sensitive in vivo applications.
Customizable mechanical properties
X-Pure is customizable, allowing you to recreate the specific mechanical cues of a cell's natural extracellular matrix and precisely control biodegradability. Compressive and elastic moduli range from a few kPa to several hundred kPa, and degradation times can vary from days to months. See Figure 1.
Figure 1: Customizable mechanical properties
References
- IPEC. Excipient Good Manufacturing Practices Guide, 2022
- Heinrich, M.A., M. Mangia, and J. Prakash. 2021. Impact of endotoxins on bioengineered tissues and models. Trends Biotechnol.
Figure 1: Customizable mechanical properties