About

We repurpose and recycle materials from the animal agriculture and food industries – transforming them into essential ingredients that do everything from feeding animals to fertilizing crops to fueling planes and nourishing people.

Solutions

As a world leader in circularity, we transform materials from the animal agriculture and food industries into valuable ingredients. Ingredients that nourish people, feed animals and crops, and fuel the world with renewable energy. This is supported through three segments within our operations: Feed, Food and Fuel.

Essential ingredients for animal nutrition, fertilizers and renewable fuels.

Ingredients to enhance human health and wellbeing.

Powering the future with low-emission energy solutions.

Brands

Our brands span more than 260 facilities across the world, transforming more than 16 million metric tons of raw material into over 350 sustainable ingredients every year.

Sustainability

Sustainability is our business. As the world’s leading practitioner of circularity, we transform unused resources into valuable ingredients that nourish people, feed animals and crops, and fuel the world with renewable energy. Our innovations help reduce landfill and minimize emissions on a global scale.

Investors

We are a leader in circularity — showcasing that sustainability and profitability can go hand-in-hand.

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Careers

At Darling Ingredients, passion meets purpose and every individual makes a difference. Explore the diverse range of career opportunities we offer around the world.

Jobs outside the U.S.

Jobs in the U.S.

Media

News, stories and events.

Gelatin for Plasma Volume Replacer (PVR)

Gelatin-based PVR effectively manages blood loss in emergencies and surgeries, offering a temporary alternative to blood transfusions. Rousselot’s lime bone gelatins meet the highest standards in this field.

Innovation

Why is gelatin used in PVR?

Gelatin, a natural protein derived from collagen, is an ideal choice for plasma volume replacers (PVRs) due to its unique properties:

Non-toxic and biocompatible: Gelatin is safe for intravenous administration and well-tolerated by the human body.Volume-expanding: Gelatin-based PVRs effectively mimic the volume-expanding properties of blood plasma, replacing up to 40% of animal and 10-20% of human blood.Superior to starch substitutes: Gelatin PVRs offer several advantages over starch-based substitutes, including no side effects, short retention times, and no accumulation.

The first documented intravenous use of gelatin as a blood plasma substitute for treating clinical shock occurred in 1915.¹ Its potential was largely forgotten until World War II, when the demand for plasma substitutes reignited interest in gelatin’s possibilities.

3 ways to produce gelatin-based PVR from a gelatin solution

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Hydrolyzation

To achieve the appropriate molecular weight for maintaining blood pressure compatibility.

Chemical modification

of the molecule from a linear to a globular conformation, enhancing compatibility with the body.

Expandable

Gelatin can expand by up to 200%, providing a physical barrier to bleeding.

References

Hogan, JJ. The intravenous use of colloidal (gelatin) solutions in shock. Jama. 1915;lxiv(9):721–726. Doi:10.1001/jama.1915.02570350015004.

Resources

Related

The importance of gelatin in pharmaceutical and medical applications

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