Gelatin for Plasma Volume Replacer (PVR)
Gelatin-based PVR effectively manages blood loss in emergencies and surgeries, offering a temporary alternative to blood transfusions. Rousselot’s lime bone gelatins meet the highest standards in this field.
Insights
Why is gelatin used in PVR?
Gelatin, a natural protein derived from collagen, is an ideal choice for plasma volume replacers (PVRs) due to its unique properties:
- Non-toxic and biocompatible: Gelatin is safe for intravenous administration and well-tolerated by the human body.
- Volume-expanding: Gelatin-based PVRs effectively mimic the volume-expanding properties of blood plasma, replacing up to 40% of animal and 10-20% of human blood.
- Superior to starch substitutes: Gelatin PVRs offer several advantages over starch-based substitutes, including no side effects, short retention times, and no accumulation.
The history of gelatin as a blood plasma substitute
The first documented intravenous use of gelatin as a blood plasma substitute for treating clinical shock occurred in 1915.1 Its potential was largely forgotten until World War II, when the demand for plasma substitutes reignited interest in gelatin’s possibilities.
Applications
3 ways to produce gelatin-based PVR from a gelatin solution
Hydrolyzation
To achieve the appropriate molecular weight for maintaining blood pressure compatibility.
Chemical modification
of the molecule from a linear to a globular conformation, enhancing compatibility with the body.
Expandable
Gelatin can expand by up to 200%, providing a physical barrier to bleeding.
Expert services
Worldwide support and expertise
Take advantage of our expert services to help select the right gelatin and formulate with ease.
Resources
Related
The importance of gelatin in pharmaceutical and medical applications
Links
Additional information
Webshop (research and technical grades)
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References
- Hogan, JJ. The intravenous use of colloidal (gelatin) solutions in shock. Jama. 1915;lxiv(9):721–726. Doi:10.1001/jama.1915.02570350015004.