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Gelatin for wound healing

Helping the body heal: Rousselot’s gelatin-based solutions for safe and effective wound healing. Advanced wound care often requires intervention to prevent infection, manage moisture content, and promote wound healing. Gelatin-based dressings provide an effective solution that promotes tissue regeneration and can help to manage complex wounds.
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Wound healing

Effective wound care solutions

Advanced wound care often requires intervention to prevent infection, manage moisture content, and promote wound healing. Gelatin-based dressings provide an effective solution that promotes tissue regeneration and can help to manage complex wounds.
Unique functionalities and properties

Why is gelatin used in wound care?

Gelatin-based dressings provide an effective solution that promotes tissue regeneration and can help to manage complex wounds. Gelatin's water-binding ability, scaffolding properties, and enzyme regulation make it indispensable in these solutions, promoting effective healing and minimizing the risk of complications.
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Maintaining optimal moisture balance
One of gelatin’s key functionalities is its ability to bind water, which helps maintain an optimal moisture balance in the wound bed. This ensures that the necessary cellular activities for healing can occur.
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An excellent scaffold for cells
Gelatin provides a structure that supports the recruitment, attachment, and growth of endogenous cells, facilitating the natural healing process. This scaffold mimics the extracellular matrix, promoting cell adhesion, migration, and proliferation, all of which are essential for tissue regeneration.1,2
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Protecting the wound bed
Gelatin plays a vital role in reducing enzyme activity in the wound bed. Dressings containing native collagen, a component of gelatin, act as a substrate magnet for elastase and matrix metalloproteinases (MMPs). These enzymes, when overexpressed, can degrade tissue and impede healing. By binding these enzymes, gelatin helps protect the wound bed from excessive enzymatic activity, promoting a more conducive environment for healing.3
Advanced solutions

Applications of gelatin in advanced wound care

Gelatin is used in advanced wound care through its application in hydrocolloid wound dressings and hydrogel sheets, particularly for large open wounds. Studies have demonstrated the effectiveness of these gelatin-based dressings in enhancing wound healing outcomes.3,4

 

Hydrocolloid wound dressings

Gelatin-based hydrocolloid dressings provide a moist environment conducive to healing, preventing the wound bed from drying out and ensuring proper cellular activities. The hydrocolloid matrix absorbs exudate, reducing the risk of infection. This type of dressing is particularly effective in managing moderate to heavily exuding wounds, creating a protective barrier that minimizes the risk of contamination and mechanical injury.

 

Hydrogel sheets

Gelatin hydrogel sheets offer a versatile solution for wound care. These sheets are composed of a gelatin matrix that retains a significant amount of water, providing a cooling and soothing effect to the wound site. Hydrogels create a moist environment that promotes cell migration and proliferation. Additionally, hydrogel sheets can conform to the wound's shape, ensuring full coverage and protection, which is crucial for irregularly shaped wounds or those located in difficult-to-dress areas.

Medical grade gelatins

Rousselot’s solutions for wound healing

Rousselot’s wound care solutions include Quali-Pure®, which offers effective wound healing with controlled endotoxin levels, and X-Pure® gelatins and modified gelatins, which provide safe and effective internal wound healing due to their low endotoxin levels, ensuring optimal healing outcomes.
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Quali-Pure
Clinical-grade, endotoxin-controlled gelatins for medical applications
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X-Pure
A range of medical-grade gelatins
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X-Pure GelMA
The world’s first GMP grade gelatin methacryloyl
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X-Pure GelDAT
The world’s first purified gelatin desaminotyrosine
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Additional information

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References

  1. Bello, A.B., Kim, D., Kim, D., Park, H. and Lee, S.H., 2020. Engineering and Functionalization of Gelatin Biomaterials: From Cell Culture to Medical Applications. Tissue Engineering Part B: Reviews, 26(2), pp.164-18
  2. Zheng, Y., Liang, Y., Zhang, D., Sun, X., Liang, L., Li, J. and Liu, Y.N., 2018. Gelatin-based hydrogels blended with gellan as an injectable wound dressing.ACS omega, 3(5), pp.4766-4775
  3. Fleck CA, Simman R. Modern collagen wound dressings: function and purpose. J Am Col Certif Wound Spec. 2011 Aug 1;2(3):50-4. doi: 10.1016/j.jcws.2010.12.003. PMID: 24527149; PMCID: PMC3601889.
  4. Brumberg V, Astrelina T, Malivanova T, Samoilov A. Modern Wound Dressings: Hydrogel Dressings. Biomedicines. 2021 Sep 16;9(9):1235. doi: 10.3390/biomedicines9091235. PMID: 34572421; PMCID: PMC8472341.
Resources

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