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Drug delivery

Purified gelatin can enhance drug delivery by protecting the active ingredient and releasing it in a controlled manner. Gelatin’s polyampholytic nature stabilizes various Active Pharmaceutical Ingredients (APIs), and its biocompatibility and tunable physical properties, allows for a range of delivery systems, from injectable gels to solid implants.
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Why X-Pure?

Discover our ultra-pure GMP-grade gelatins for drug delivery

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X-Pure GelMA
lets you fine-tune rheological properties by adjusting modification levels and molecular weight, delivering unmatched versatility for drug delivery systems2
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X-Pure GelDAT
is the world’s first purified gelatin desaminotyrosine, featuring crosslinking cues for stability at 37°C and seamless integration with other biomaterials
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Unique functionalities and properties

X-Pure for drug delivery

Localized or sustained drug delivery involves numerous challenges, influenced by the nature of the API and the desired delivery method. Rousselot’s pharmaceutical-grade gelatin portfolio offers unique properties that make it a suitable carrier for effective drug delivery across a range of applications:

  • Microneedles: Customizable, and ensures uniform patch fabrication and scalable production.
  • Implants: Tailored for precise control over release rates, texture, dosage, and pharmacokinetics.
  • Shear thinning: Allowing easy injection and subsequent fixation of the API at the target location.
  • Micro- and submicro-particles: Moldable into various structures for targeted and controlled release
Insights

Why choose gelatin for drug delivery?

Gelatin’s natural properties make it a crucial resource in regenerative medicine, contributing to the advancement of therapies that repair or regenerate damaged tissues and organs.
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Excellent biodegradability
Gelatin, a protein derived from collagen, is naturally degraded by enzymes in the body (metalloproteinases).
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No immune response
Gelatin is biocompatible and does not trigger an immune response.
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Compatible with multiple APIs
Because gelatin stabilizes proteins and protects cell membranes, it is versatile and can be used with various APIs, RNA, DNA, and biologics.
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Versatility in dosage form
Gelatin can be turned into various physical forms—like micro and nano-spheres, gel films, sponges, sheets, shear thinning liquids, putties, pastes, hydrogels, microneedles, and implants—to ensure targeted, controlled release for both large and small molecules.1
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Tunable release
By selecting the right gelatin properties and crosslinking parameters, gelatin can be fine-tuned to optimize both drug release and degradation kinetics.
Resources

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References

  1. Nikkhah, Medhi, Mohsen Akbari, Arghya Paul, Adnan Memic, Alireza Dolatshahi- Pirouz, and Ali Khademhosseini. 2016. Gelatin-based biomaterials for tissue engineering and stem cell bioengineering. In Biomaterials from Nature for Advanced Devices and Therapies, by Nuno M Never and Rui I Reis, 37-62. John Wiley & Sons, Inc.
  2. Pepelanova, I., Kruppa, K., Scheper, T. and Lavrentieva, A., 2018. Gelatin-Methacryloyl (GelMA) hydrogels with defined degree of functionalization as a versatile toolkit for 3D cell culture and extrusion bioprinting. Bioengineering, 5(3), p.55